BCR–ABL and CDKN2A: a dropped connection
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چکیده
منابع مشابه
Nilotinib based pharmacophore models for BCRABL
UNLABELLED Tyrosine kinase inhibitors have revolutionized the treatment of several malignancies, converting lethal diseases in a manageable aspect. Imitanib, a small molecule ABL kinase inhibitor is a highly effective therapy for early phase chronic myeloid leukemia (CML), which has constitutively active ABL kinase activity owing to the over expression of the BCR-ABL fusion protein. But some pa...
متن کامل[Dropped head and negative dystonia].
2013 年 6 月 9 日 拝啓 本誌第 53 巻 6 号に掲載されました原著「種々の疾患にと もなう首下がり症候群の病態生理学的分析―表面筋電図所見 と理学療法の効果から」(臨床神経 2013;53:430-438)を興 味深く拝読いたしました.「首下がり」は治療に難渋する症 状です.一部の患者で理学療法が有効であるとのご報告は, 今後の診療上,大変参考になりました. ここで私見を三点申し述べたく存じます. 第 1 は,「首下がり」という用語についてです.現在, “dropped head”は原因を問わず「首下がり」と訳されますが, 「首下がり」の原義は,主に東北地方で風土病として知られ, 中野健隆が 1888 年に報告した病態を指します.1897 年に三 浦謹之助が“Kubisagari”として総括しました.わが国で昭 和以降の報告はなく,病因など一切が不明のまま消滅したと 考...
متن کاملA Case of Dropped Head plus Syndrome
UNLABELLED A patient developed neck extensor weakness along with symmetrical, mild proximal extremity weakness. Electrodiagnostic findings were minimal. Subsequently muscle biopsy was undertaken which showed myopathic changes as well as rimmed vacuoles. This case highlights the discussion of histopatholgical findings seen in neck extensor weakness when it occurs in isolation as well as when it ...
متن کاملManagement of a Dropped Autologous Skin Graft
DESCRIPTION A 67-year-old man underwent full-thickness skin graft reconstruction of an ear defect following skin cancer excision. The graft was dropped on the floor during preparation. Following decontamination, it was subsequently used to complete the reconstruction, with full graft take and no evidence of infection after 4 months of follow-up.
متن کاملA Novel Approach to Dropped Pronoun Translation
Dropped Pronouns (DP) in which pronouns are frequently dropped in the source language but should be retained in the target language are challenge in machine translation. In response to this problem, we propose a semisupervised approach to recall possibly missing pronouns in the translation. Firstly, we build training data for DP generation in which the DPs are automatically labelled according t...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2008
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2368-c1